This phenomenon is called post-prandial alkaline tide. HCO 3 – will enter blood and hence pH of blood becomes more alkaline.
More H + ions being utilized, more HCO 3 –, ions secreted outside. Immediately following a meal, pepsin and HCI secretion are increased. The canaliculus is in direct continuation with gastric gland which enters the stomach through the gastric pit. Thus it is proved that H + and CI – are actively secreted into the canaliculus where the coupling occurs to form HCI. ATF is readily available from metabolism of carbohydrates inside the parietal cells to supply the energy required for the activity of the pump.ĬI – enters the parietal cell from plasma in two ways: This H +-K + pump activity requires the energy supply. The H + ion formed because of ionization of water is pumped into the intracellular canaliculus in exchange for K +. One of the drugs used to block the action of carbonic anhydrase is acetazolamide (diamox). If carbonic anhydrase action is blocked, the entire HCI secretion is inhibited. H 2CO 3 dissociates to yield H + ion and HCO 3 – ion. It is neutralized in the following manner: CO 2 produced inside the cell and also contributed from plasma combines with water in presence of carbonic anhydrase (CA) to yield H 2CO 3. States that H + ions in the parietal cells are obtained by active ionization of water yielding H + and OH – ions OH – should not be allowed to accumulate inside the cell.
0 kommentar(er)
